After moving to New York in 1983, he began to study printmaking at The New School, Pratt Graphics Center and Manhattan Graphics Center. Mershimer was initially drawn to the slow, direct and laborious mezzotint process, because it echoed his approach to drawing. In 2007, Stone and Press published a catalogue raisonné of his work, titled Frederick Mershimer Mezzotints 1984 – 2006. In 2007, he received an Artist Fellowship Grant from the New York Foundation for the Arts, followed by a 2009 Individual Support Grant from the Adolph and Esther Gottlieb Foundation. His works is in the collections of The Brooklyn Museum of Art, Library of Congress, Museum of the City of New York, The National Museum of American Art-Smithsonian, New Orleans Museum of Art, The New York Public Library, Queens Museum of Art, The Whitney Museum of American Art, and Zimmerli Museum, among others.